Identification and clearance of high-level drug-resistant Salmonella Kentucky ST198.2-1 from an occupational health examinee
10.3760/cma.j.cn114452-20231220-00368
- VernacularTitle:自职业体检者检出和清除高水平耐药肯塔基沙门菌ST198.2-1
- Author:
Yan ZHONG
1
;
Jingfang RUAN
;
Xiachan QIN
;
Bei WEI
;
Yue LIU
;
Min ZHOU
;
Xuebin XU
Author Information
1. 贵港市覃塘区人民医院检验科，贵港 537121
- Keywords:
Salmonella;
Serotyping;
Genome;
Database;
Clone
- From:
Chinese Journal of Laboratory Medicine
2024;47(9):1094-1097
- CountryChina
- Language:Chinese
-
Abstract:
A 49-year-old female examinee, employed at a paper company in Guigang, Guangxi (engaged in the production of napkins), visited the Qintang District People′s Hospital in Guigang on June 11, 2023, to apply for a health certificate. Salmonella was isolated during a physical examination screening for enteric pathogens ( Salmonella, Shigella), and repeated use of empirical antibacterial drugs failed to eradicate the pathogen. A reference laboratory identified the two isolates as S. Kentucky ST198 by performing serotyping, drug resistance phenotyping, and whole genome sequencing. Based on the regional serotype database of Salmonella in China, a phylogenetic tree of S. Kentucky ST198 resistance genotypes was constructed, defining both isolated strains as high-level drug-resistant ST198.2-1 subclade clones. Following a multidisciplinary consultation and based on antimicrobial susceptibility test results, the treatment was adjusted to amoxicillin/clavulanate and azithromycin. On August 19, three consecutive negative test results confirmed the eradication of Salmonella Kentucky.
