Clinical application progress of flow cytometry in diagnosis and therapeutic monitoring of patients with nonhematopoietic neoplasms

VernacularTitle:流式细胞术在非造血系统肿瘤诊断和治疗监测中的临床应用进展
Author: Qianwen HU ¹ ; Suwen YANG ; Sai QIAO ; Xinyou XIE ; Jun ZHANG
Author Information

1. 浙江大学医学院附属邵逸夫医院检验科　浙江省医学精准检验与监测研究重点实验室，杭州　310000
Keywords: Flow cytometry; Clinical laboratory techniques; Mass spectrometry flow cytometry; Spectral flow cytometry; Neoplasms
From: Chinese Journal of Laboratory Medicine 2024;47(7):722-728
CountryChina
Language:Chinese
Abstract: Flow cytometry (FCM) is an interdisciplinary cell analysis technology that integrates optics, fluid dynamics, electronics, and computer science. While FCM is widely utilized in diagnosing and monitoring hematologic malignancies, its application in nonhematopoietic neoplasms (NHN) remains in its nascent stages. However, recent advancements in science and technology have led to the emergence of innovative FCM technologies, such as mass spectrometry flow cytometry (CyTOF) and spectral flow cytometry (SFC), offering promising avenues for their clinical application aiming to assist the clinical diagnosis of NHN patients. This review summarizes the features of fundamentals of traditional FCM, CyTOF, and SFC technologies, along with their applications and future prospective in NHN diagnosis and treatment, aiming to offer updated insights for the continued expansion and utilization of FCM technology in clinical laboratory settings.