Isolation and antifungal resistance analysis of 10 strains of Candida auris
10.3760/cma.j.cn114452-20240301-00103
- VernacularTitle:10株耳念珠菌的分离及耐药性分析
- Author:
Li LIN
1
;
Shuai ZU
;
Hengrui ZHAO
;
Jingyu WANG
;
Lei ZHENG
;
Xiumei HU
Author Information
1. 南方医科大学南方医院检验科，广州 510510
- Keywords:
Candida auris;
Fungal infection;
Drug resistance;
Healthcare-associated infection;
Prevention and control
- From:
Chinese Journal of Laboratory Medicine
2024;47(6):644-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Analyze the isolation and antimicrobial resistance of Candida auris.Methods:Using matrix-assisted laser desorption ionization time-of-flight mass spectrometry, 10 clinically isolated strains of Candida auris were identified in Nanfang Hospital of Southern Medical University between September and December 2023. Additionally, their resistance to multiple antifungal drugs, specimen source, and patient prognosis were analyzed. Results:All 10 isolates were identified as Candida auris by mass spectrometry. The drug sensitivity test showed that 10 strains were resistant to fluconazole, 3 strains were resistant to amphotericin B, and all were sensitive to Echinocandins. The samples came from various sources; except for 2 patients who were in good condition, 1 patient with stable condition were discharged, and 1 patient died, the remaining 6 patients voluntarily discharged due to worsening of their condition. Conclusions:Candida auris can be identified by mass spectrometry. It was found that Candida auris had high resistance to fluconazole and no resistance to echinocanthin.
