Research progress of retinal pigment epithelial cell transplantation in the treatment of retinitis pigmentosa
10.3760/cma.j.cn511434-20240619-00233
- VernacularTitle:视网膜色素上皮细胞移植治疗色素性视网膜炎的研究进展
- Author:
Yunxi ZHANG
1
;
Boshi LIU
;
Dongjun XING
;
Xiaorong LI
Author Information
1. 天津医科大学眼科医院、眼视光学院、眼科研究所 国家眼耳鼻喉疾病临床医学研究中心天津市分中心 天津市视网膜功能与疾病重点实验室, 天津 300384
- Keywords:
Retintis pigmentosa;
Retinal pigment epithelium;
Cell therapy;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(11):893-897
- CountryChina
- Language:Chinese
-
Abstract:
Retinitis pigmentosa (RP) is a genetic disorder of photoreceptor cell apoptosis and retinal pigment epithelium (RPE) cell atrophy caused by gene mutation. The clinical manifestations are night blindness, peripheral visual field loss and progressive vision loss. RPE cell apoptosis plays an important role in the progression of RP, and exogenous implantation of RPE cells as an alternative therapy has shown certain efficacy in animal experiments and clinical trials. With the diversification of cell sources, the update of surgical techniques and the continuous emergence of biological materials, more possibilities and hopes are provided for cell therapy. To further promote the development of this field in the future, it is still necessary to strengthen the cooperation between medicine, bioengineering and other disciplines in the future to jointly promote the innovation and development of therapeutic methods. It is believed that RPE cell transplantation therapy will show a brighter prospect in the future
