Research progress on the role of microglial glucose metabolism reprogramming in age-related macular degeneration

VernacularTitle:小胶质细胞糖代谢重编程在年龄相关性黄斑变性中作用的研究进展
Author: Yue ZOU ¹ ; Xin TAN ; Yunqin LI
Author Information

1. 云南大学附属医院眼科，昆明　650021
Keywords: Age-related macular degeneration; Microglial; Glucose metabolism reprogramming; Review
From: Chinese Journal of Ocular Fundus Diseases 2024;40(10):819-824
CountryChina
Language:Chinese
Abstract: Age-related macular degeneration (AMD) involves dysregulation of the innate immune response of complement and mononuclear phagocytes and abnormalities of local microglia. When microglia transition from a resting state to an active state, their metabolic pathway also changes, known as "metabolic reprogramming", and their glucose metabolic reprogramming is a key factor in the pathogenesis of AMD, involving multiple signaling pathways. Including phosphatidylinositol 3-kinase-serine threonine kinase-rapamycin target, adenylate activated protein kinase and hypoxia-inducing factor 1 pathway. These metabolic changes regulate the inflammatory response, energy supply, and neuroprotective functions of microglia. Therapeutic strategies to regulate the reprogramming of glucose metabolism in microglia have achieved initial results. Future studies should further explore the mechanisms of microglia metabolic regulation to develop new targeted drugs and intervene in the treatment of AMD through anti-cellular aging pathways.