Research progress on the mechanism and potential treatment of oxidative stress in diabetic retinal neurodegeneration
10.3760/cma.j.cn511434-20240422-00162
- VernacularTitle:氧化应激在糖尿病视网膜神经变性中的作用机制与潜在治疗的研究进展
- Author:
Jiapeng WANG
1
;
Xiangxia LUO
;
Jiayuan ZHUANG
;
Wanying GUO
;
Yutong WU
;
Mingli DAI
Author Information
1. 甘肃中医药大学中医临床学院，兰州 730000
- Keywords:
Diabetic retinopathy;
Diabetic retinal neurodegeneration;
Oxidative stress;
Retinal neurovascular unit;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(10):813-818
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinal neurodegeneration is a serious complication of diabetes mellitus, manifested by apoptosis and gliosis, and its pathogenesis is closely related to the oxidative stress induced by high glucose levels. The increase in blood glucose in the body leads to excessive production of reactive oxygen species and the downregulation of antioxidant defense signaling pathways, which leads to oxidative stress in the body, which in turn induces apoptosis, mitochondrial damage and autophagy, resulting in diabetic retinal neurodegeneration. Antioxidant stress therapy with gene therapy, flavonoids, recombinant Ad-β-catenin carriers, and autophagy inducers to exert neuroprotective effects. In the future, more clinical trials are needed to explore the effective dosage and side effects of drugs, and to develop new drugs and treatment strategies for oxidative stress to prevent and treat diabetic retinal neurodegeneration and protect retinal nerve function.
