Secondary Primary Prostate Cancer after Colorectal Cancer: A Nationwide Population-based Cohort Study in Korea.
10.15430/JCP.2017.22.4.241
- Author:
Hyun Soo KIM
1
;
Yoon Jin CHOI
;
Dong Woo SHIN
;
Kyung Do HAN
;
Hyuk YOON
;
Cheol Min SHIN
;
Young Soo PARK
;
Nayoung KIM
;
Dong Ho LEE
Author Information
1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. dhljohn@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasm;
Prostatic neoplasm;
Second primary neoplasms
- MeSH:
Body Mass Index;
Cohort Studies*;
Colorectal Neoplasms*;
Dataset;
Developed Countries;
Diabetes Mellitus;
Diagnosis;
Dyslipidemias;
Follow-Up Studies;
Humans;
Hypertension;
Incidence;
Korea*;
Male;
Mass Screening;
Multivariate Analysis;
National Health Programs;
Neoplasms, Second Primary;
Proportional Hazards Models;
Prostate*;
Prostatic Neoplasms*;
Republic of Korea;
Survivors
- From:Journal of Cancer Prevention
2017;22(4):241-247
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Colorectal cancer (CRC) and prostate cancer frequently occur in developed countries. There are several reports on the association between CRC and prostate cancer; however, the conclusions are inconsistent to investigate the association of the development of secondary primary prostate cancer among patients with prior primary CRC using a nationwide population-based dataset. METHODS: Patients registered in the Republic of Korea National Health Insurance System database who were diagnosed with CRC between 2007 and 2012 were followed-up until the end of 2015, and we investigated the new diagnosis secondary primary prostate cancer. We compared the incidence of prostate cancer in age-matched controls using the Cox proportional hazards models. RESULTS: We analyzed a total of 85,455 first primary CRC survivors. During the follow-up period of 494,222 person-years, 2,005 patients (2.30%) developed secondary primary prostate cancer (incidence rate 4.06/1,000 person-years). The median duration of follow-up was 5.78 years. Compared with the general population, CRC patients had a significantly increased risk of secondary primary prostate cancer (HR = 2.30, 95% CI = 2.18–2.43; P < 0.001). Multivariate analysis (including age, sex, body mass index, hypertension, diabetes mellitus, dyslipidemia, and income) showed that age < 55 years (HR = 20.74, 95% CI = 11.81–36.41; P < 0.001) is a significant independent predictor of secondary primary prostate cancer development. CONCLUSIONS: Men diagnosed with colorectal cancer are at an increased risk of secondary primary prostate cancer, particularly those aged < 55 years. The data suggests that colorectal cancer patients aged < 55 years require regular screening for prostate cancer.
