Research progress on the pathogenesis of hydroxychloroquine retinopathy and the related fundus changes
10.3760/cma.j.cn511434-20231226-00509
- VernacularTitle:羟氯喹视网膜病变发病机制及相关眼底改变的研究进展
- Author:
Yongfang ZHONG
1
;
Xuemei XU
;
Haibin WANG
Author Information
1. 承德医学院附属医院眼科, 承德 067000
- Keywords:
Hydroxychloroquine;
Retinopathy;
Fundus changes;
Pathogenesis;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(9):729-732
- CountryChina
- Language:Chinese
-
Abstract:
Hydroxychloroquine retinopathy is an ocular lesions that develops following long-term or excessive use of hydroxychloroquine. The early clinical presentation of this lesion is nonspecific and is often detected when severe central vision impairment occurs in late stage. It currently mainly includes hydroxychloroquine binding to melanin, inducing degeneration of the retinal pigment epithelium, increasing the pH of lysosomes in the retinal pigment epithelium and interfering with the visual cycle. In recent years, with the development of retinal imaging technology and the in-depth study of hydroxychloroquine retinopathy, characteristic fundus structural changes such as retinal and choroidal thickness and blood vessels may occur in the early stage. This not only provides an important basis for the early diagnosis of hydroxychloroquine retinopathy, but also provides important clues for investigating its pathogenesis. Clinicians' proficiency in relevant fundus changes and pathogenesis will facilitate early diagnosis and treatment, while also minimizing irreversible central vision impairment in patients.
