Research progress in the role and mechanism of angiopoietin-like protein in diabetic retinopathy

VernacularTitle:血管生成素样蛋白在糖尿病视网膜病变中作用与机制的研究进展
Author: Ye TIAN ¹ ; Guoheng ZHANG ; Guorui DOU
Author Information

1. 空军军医大学西京医院眼科　全军眼科研究所，西安　710032
Keywords: Angiopoietin-like protein; Diabetic retinopathy; Molecular mechanism; Targeted drug; Review
From: Chinese Journal of Ocular Fundus Diseases 2024;40(7):569-574
CountryChina
Language:Chinese
Abstract: Angiopoietin-like protein (ANGPTL), a group of secreted glycoproteins, is widely expressed in vivo and is involved in many pathophysiological processes such as glycolipid metabolism, stem cell growth, local inflammation, vascular leakage and angiogenesis. Many kinds of ANGPTL are closely related to the occurrence and development of diabetic retinopathy (DR), especially ANGPTL4, which has gradually become a new hotspot in the field of DR Research. ANGPTL is involved in glucose metabolism and lipid metabolism, promotes increased vascular permeability, pathological angiogenesis, and participates in intraocular inflammation. ANGPTL is a promising molecular target. It can not only be used as a biomarker to predict the occurrence and progression of DR, but also provide new ideas for the treatment of DR by making antibody drugs to interfere with this molecule.