Research progress of fundus changes in severe beta thalassemia

VernacularTitle:重型β地中海贫血眼底变化的研究进展
Author: Wenwen LI ¹ ; Danna CHEN ; Yongcan WEI ; Quanwen ZHAO ; Guiling ZHAO
Author Information

1. 广东医科大学附属医院眼科,　广州　524002
Keywords: Thalassemia; Retina; Optic nerve; Fundus changes; Review
From: Chinese Journal of Ocular Fundus Diseases 2024;40(4):329-333
CountryChina
Language:Chinese
Abstract: β thalassemia is a hereditary hemolytic disease caused by the defect of β globin gene. Transfusion-dependent β thalassemia patients need long-term blood transfusion to survive, and a series of systemic and ocular complications will occur in the disease itself and long-term blood transfusion. Retinal blood vessel density decreases, retinal thickness thinned and elastic pseudoxanthoxanoma syndrome are found in fundus due to long-term anemia and side effects of iron chelating agent. At present, there are few reports about eye changes in thalassemia patients, and the cognition is relatively scarce. Therefore, it is necessary to be vigilant for physicians, deeply explore the cause and symptomatic treatment, combined with individual disease characteristics, to provide a more scientific and accurate plan for clinical treatment.