Research progress of single cell transcriptomics in ocular fundus diseases

VernacularTitle:单细胞转录组学在眼底疾病领域的研究进展
Author: Xiying MAO ¹ ; Wenjie YIN ; Miao XU ; Songtao YUAN ; Qinghuai LIU
Author Information

1. 南京医科大学第一附属医院眼科,　南京　210029
Keywords: Single-cell RNA sequencing; Ocular fundus diseases; Shared database; Review
From: Chinese Journal of Ocular Fundus Diseases 2024;40(3):243-246
CountryChina
Language:Chinese
Abstract: Single cell RNA sequencing technique provides a strong technical support for the analysis of cell heterogeneity in biological tissues, and has been widely used in biomedical research. In recent years, considerable scRNA-seq data have been accumulated in the research of ocular fundus diseases. The ocular fundus is abundant for the network of vessel and neuron, which leads to the complicated pathogenesis of fundus diseases. Through single cell RNA sequencing technique, the expression of thousands of genes of certain cell types or even subtypes can be obtained in the disease environment. Single cell RNA sequencing technique accurately reveals the pathogenic cell types and pathogenic mechanisms of ocular fundus diseases such as neovascular retinopathy, which provides a theoretical basis for the birth of new diagnosis and treatment targets. The construction of multi-omics single-cell database of ocular fundus diseases will enable high-quality data to be further explored and provide an analysis platform for ophthalmic researchers.