Report of 5 gene-edited pig-rhesus monkey heterotopic heart xenotransplantation experiment
10.3760/cma.j.cn112434-20240204-00038
- VernacularTitle:5基因编辑猪－恒河猴异种心脏移植实验报道
- Author:
Gen ZHANG
1
;
Huan WANG
;
Yulong GUAN
;
Jie YAN
;
Ji LI
;
Xiaoliang LI
;
Xianhua LI
;
Rong ZHOU
;
Xianzhi WANG
;
Zhipeng REN
;
Dongsheng HE
;
Xin LI
;
Dengke PAN
;
Dianyuan LI
Author Information
1. 南京医科大学姑苏学院附属苏州医院心血管外科，苏州 215000
- Keywords:
Gene-edited pig;
Rhesus monkey;
Heart xenograft;
Immunological rejection
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2024;40(6):379-384
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changing trends in cardiac function following xenogeneic heterotopic heart transplantation of multi-gene edited pig hearts and assess the impact of recipient immune responses on donor heart, laying experimental groundwork for the clinical application of gene editing technology.Methods:On December 16, 2023, xenogeneic heterotopic heart transplantation was performed between pigs and rhesus monkeys. Functional status of the graft under post-transplantation load conditions and recipient immune indicators were observed.Results:The recipient monkeys survived for 40 days with satisfactory functionality of both donor and recipient hearts, and no hyperacute or acute immune rejection reactions were observed.Conclusion:Multi-gene editing technology provides potential for xenotransplantation, yet further exploration is needed for its clinical application.
