Effect of Helicobacter pylori eradication therapy on intraoperative bleeding during gastric endoscopic submucosal dissection in a short term
10.3760/cma.j.cn321463-20240108-00010
- VernacularTitle:幽门螺杆菌除菌治疗后短期内对胃内镜黏膜下剥离术中出血的影响分析
- Author:
Xiaohan YAN
1
;
Li ZHANG
;
Tao CHEN
;
Jingze LI
;
Jingjing LIAN
;
Qinwei XU
;
Meidong XU
Author Information
1. 上海市东方医院消化医学部消化内镜科，上海 200120
- Keywords:
Helicobacter pylori;
Early gastric cancer;
Endoscopic submucosal dissection;
Intraoperative bleeding
- From:
Chinese Journal of Digestive Endoscopy
2024;41(8):614-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the short-term effect of Helicobacter pylori ( HP) eradication on intraoperative bleeding during endoscopic submucosal dissection (ESD) for early gastric cancer. Methods:Patients who underwent ESD for early gastric cancer in Shanghai East Hospital from September 2021 to September 2023 were retrospectively analyzed for endoscopic, pathological and clinical data. The patients with current HP infection were included in the current infection group, and those who underwent eradication therapy within 10 weeks and successfully eradicated were included in the short-term after eradication group. The occurrence of intraoperative bleeding was compared. Results:A total of 345 patients were analyzed, with 156 in the current infection group and 189 in the short-term after eradication group. Compared with the current infection group, short-term after eradication group was effective in reducing the intraoperative bleeding rate [6.3% (12/189) VS 12.8% (20/156), χ2 =4.253, P=0.039] and significantly reduced the duration of operation (29±9 min VS 38±14 min, t=2.667, P=0.008). Intraoperative bleeding was significantly reduced in short-term after eradication group in lesions of the upper 1/3 of the stomach [12.5% (5/40) VS 32.1% (9/28), χ2 =3.887, P=0.049], while there were no significant differences in intraoperative bleeding between the current infection group and the short-term after eradication group in lesions of the middle 1/3 [5.4% (2/37) VS 10.0% (3/30), χ2 =0.506, P=0.477] and lower 1/3 [4.5% (5/112) VS 8.2% (8/98), χ2 =1.231, P=0.267] of the stomach. Conclusion:HP eradication therapy can effectively reduce intraoperative bleeding in ESD and significantly reduce the duration of operation in a short-term. For individuals with early gastric cancer and HP infection, undergoing eradication therapy before ESD is recommended, particularly for lesions situated in the upper 1/3 of the stomach.
