Progress in host proteins interacting with encephalomyocarditis virus and their roles
10.3760/cma.j.cn112309-20230919-00083
- VernacularTitle:与脑心肌炎病毒互作的宿主蛋白质及其作用研究进展
- Author:
Zhengyang HOU
1
;
Yaxin ZHANG
;
Jingying XIE
;
Yizhong LIU
;
Ruofei FENG
Author Information
1. 西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室，兰州 730030
- Keywords:
Encephalomyocarditis virus;
Virus cycle;
Host protein
- From:
Chinese Journal of Microbiology and Immunology
2024;44(11):985-991
- CountryChina
- Language:Chinese
-
Abstract:
Encephalomyocarditis virus (EMCV) is a non-enveloped, positive-sense, single-stranded RNA virus that belongs to the family Picornaviridae and the genus Cardiovirus. EMCV has the ability to infect various mammals, such as mice, pigs, and cattle. In addition, humans are susceptible to EMCV infection, and the seropositivity rate of relevant antibodies in healthy populations is steadily increasing, which poses a potential risk of epidemics. The initial step of viral infection in cells involves recognition and attachment to cell surface receptors, followed by endocytosis into the cells. Subsequently, viral proteins interact with host proteins within the cells to promote their own replication. With the progress made in protein-protein interaction studies and the development of high-throughput sequencing technologies, multiple host proteins that interact with EMCV have been identified. This article summarizes the host proteins that interact with EMCV during infection, explores the mechanisms by which these proteins facilitate or inhibit viral invasion, discusses the latest progress in EMCV-induced endocytosis and intracellular signaling, hoping to provide reference for better elucidating EMCV receptor proteins, understanding viral infection and replication mechanisms, studying virus-host interactions and tissue tropism, and developing novel targeted antiviral drugs and prevention strategies.
