Role of metabolic pathways in neutrophils in response to infection

VernacularTitle:代谢途径在中性粒细胞抗感染免疫过程中的作用
Author: Xiaolu WANG ¹ ; Jianling SU ; Shiqi FENG ; Shiping HE ; Yang LI
Author Information

1. 中山大学附属第八医院（深圳福田）综合（特需）一病区，深圳　518033
Keywords: Neutrophils; Metabolic pathways; Infection immunity
From: Chinese Journal of Microbiology and Immunology 2024;44(11):965-969
CountryChina
Language:Chinese
Abstract: Neutrophils as the first immune responders to infection can quickly identify and eliminate pathogens. The mainly rely on glycolysis to exert their killing functions. Although researches on the metabolic shifs that affect neutrophil functions began early, little is known about how neutrophils undergo metabolic transformation during the anti-infection process. It has been proven that glycogen metabolism plays an important role in regulating the functions of neutrophils. Other metabolic pathways besides glycolysis, such as mitochondrial metabolism and fatty acid oxidation during neutrophil differentiation, have potential contributions to the regulation of neutrophils′ functions. This review summaries current studies about metabolic regulatory effects of neutrophils on anti-infection responses, intending to provide reference for further study on the metabolism of neutrophils.