Carriage situation of Neisseria meningitidis among healthy population in Hebei Province from 2015 to 2022
10.3760/cma.j.cn112309-20240124-00034
- VernacularTitle:2015—2022年河北省健康人群脑膜炎奈瑟菌带菌现状
- Author:
Yuwen CAO
1
;
Leyu WANG
;
Haixia ZHANG
;
Zhaoyi JIA
;
Baohua HE
;
Ruoxuan WANG
;
Yinqi SUN
Author Information
1. 河北省疾病预防控制中心细菌病防治与消毒所，河北省传染病病原鉴定分析与流行病学重点实验室，石家庄 050021
- Keywords:
Neisseria meningitidis;
Healthy population;
Carriage rate
- From:
Chinese Journal of Microbiology and Immunology
2024;44(10):893-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the carriage status of Neisseria meningitidis ( Nm) among the healthy population in Hebei Province for the prevention and control of meningitis. Methods:From 2015 to 2022, throat swabs were collected from health people, which were selected by cluster random sampling in 11 cities of Hebei.The positive rate of Nm was detected by bacterial culture. The serogroups of isolated strains were identified.The laboratory detection results of Nm strains, combined with epidemiological survey data, were synthetically analyzed. Results:A total of 20 245 people were investigated; 249 strains of Nm were isolated; the overall Nm carriage rate was 1.23%. The carriage rate was significantly higher in men than in women(χ 2=28.831, P<0.05). The positive rates of Nm in different age groups were significantly different(χ 2=428.018, P<0.05), with the highest rates in the 15-19 year-old group(4.90%, 149/3 042). The positive rates of Nm were significantly different in different regions(χ 2=177.512, P<0.05), with the highest positive rate of Nm in Xingtai, Shijiazhuang, Chengde and Baoding city in sequence. Among the isolated Nm strains, ungroupable serogroups, serogroup B, serogroup C, and serogroup W accounted for 71.49%(178/249), 13.65%(34/249), 6.83%(17/249) and 4.42%(11/249), respectively. Conclusions:The carriage rate of Nm among healthy population is generally low in Hebei Province. It is recommended to continue to strengthen monitoring, pay attention to the changes and distribution characteristics of Nm, and formulate scientific and targeted prevention and control measures of meningococcal disease.
