Latest research progress in integron capture and cleavage of exogenous gene cassettes and expression regulatory mechanisms
10.3760/cma.j.cn112309-20240719-00268
- VernacularTitle:整合子捕获与剪切外源基因盒及其表达调控机制最新研究进展
- Author:
Tantao ZHANG
1
;
Ying HU
;
Yulin LONG
;
Linlin XIAO
Author Information
1. 安徽理工大学医学院，淮南 232001
- Keywords:
Integron;
Exogenous gene cassette;
Genetic element;
Antibiotic resistance mechanism
- From:
Chinese Journal of Microbiology and Immunology
2024;44(10):871-878
- CountryChina
- Language:Chinese
-
Abstract:
Integrons, an important system in bacteria that can capture, express, and excise exogenous genes (particularly antibiotic resistance genes), have received considerable attention in recent years. The integrons integrated onto transposons, conjugative plasmids, phages, or chromosomes can capture gene cassettes through site-specific recombination and facilitate their expression. Through a specific excision mechanism, gene cassettes can also be precisely excised and spread within bacterial populations via horizontal gene transfer and other means. This series of processes not only promotes the reconfiguration of gene cassettes and maintains diversity, but also provides flexibility for bacteria to adapt to constantly changing environments. This article will focus on the latest research advances in the capture, excision, and expression regulation mechanisms of integrons, in order to help researchers have a deeper understanding of the evolutionary trends of integrons and provide valuable insights for the study of bacterial antibiotic resistance dissemination mechanisms and the development of new antibiotics.
