Advances in the pathogenic mechanisms of uropathogenic Escherichia coli

VernacularTitle:尿路致病性大肠埃希菌致病机制研究进展
Author: Zhuoxuan LYU ¹ ; Quanjie HU ; Feng ZHANG ; Hongxia NIU
Author Information

1. 浙江中医药大学基础医学院病原生物与免疫学教研室，杭州　310053
Keywords: Urinary tract infection; Uropathogenic Escherichia coli; Virulence factors; Persistent bacteria; Pathogenic mechanisms
From: Chinese Journal of Microbiology and Immunology 2024;44(10):860-870
CountryChina
Language:Chinese
Abstract: Urinary tract infections (UTIs) are infectious diseases caused by uropathogenic bacteria, characterized clinically by high infection and recurrence rates, with uropathogenic Escherichia coli (UPEC) being the main causative agent. This bacterium possesses various virulence factors that enable it to adhere, colonize, invade, and cause disease in the bladder. This article reviews the pathogenic mechanisms of UPEC, focusing on its virulence factors, interactions with the host, and persistence in the body, aiming to expand our understanding of the processes involved in the occurrence and recurrence of UTIs.