Analysis of Lymphocyte Subsets in Peripheral Blood after Radiotherapy.
- Author:
Jung Man KIM
1
;
Hyung Sik LEE
;
Won Joo HUR
;
Jeung Kee KIM
;
Young Min CHOI
Author Information
1. Department of Radiation Oncology, College of Medicine, Dong-A University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Lymphocyte subset;
Radiotherapy
- MeSH:
B-Lymphocytes;
Cell Count;
Granulocytes;
Humans;
Killer Cells, Natural;
Leukocytes;
Lymphocyte Count;
Lymphocyte Subsets*;
Lymphocytes*;
Monocytes;
Radiation Oncology;
Radiotherapy*;
T-Lymphocytes;
T-Lymphocytes, Helper-Inducer
- From:Journal of the Korean Society for Therapeutic Radiology
1996;14(3):229-236
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the changes of differential counts and lymphocyte subsets in cancer patients' leukocyte before and after radiotherapy. METHODS AND MATERIALS: From Dec. 1994 to May 1995, the changes of leukocyte and its subsets in 16 patients who received radiotherapy in the Dept. of Radiation Oncology of Dong-A University Hospiatal were investigated. Radiation was delivered from 2700 cGy to 6660 cGy with median dose of 5400 cGy. The results of pre- and post-radiotherapy were analyzed by paired T-test. The results of patients who received < 50 Gy and > or = 50 Gy were analyzed by wilcoxon test. RESULTS: Before and after radiotherapy, there was not any significant differences in the counts of leukocyte, granulocyte and monocyte. A remarkable decrease was noted in lymphocyte counts after radiotherapy(p=0.015). T cells, B cells and natural killer cells were also decreased in number after radiotherapy but it was not significant statistically. T helper cells and T suppressor cells were also decreased in number(p>0.05). The ratio of T helper/suppressor cell was decreased from 1.52 to 1.11 and it was significant statistically(p=0.016). The portion of T suppressor cell among all T cells was increased after radiotherapy (p=0.0195). No significant difference was observed in the analysis of leukocyte and its subsets between patients who reveived < 50 Gy and > or = 50 Gy. CONCLUSION: Radiotherapy caused remarkable decrease in lymphocyte count and its subsets. Among all lymphocyte subsets, T helper cell might be the most vulnerable to radiation, considering decreased ratio of T helper/surppressor cell count after radiotherapy.
