The role of hepatic macrophages in acute liver injury
10.3760/cma.j.cn112309-20230815-00038
- VernacularTitle:肝脏巨噬细胞在急性肝损伤中的作用研究进展
- Author:
Xin YAN
1
;
Yupu HONG
Author Information
1. 福建医科大学附属第一医院肝胆胰外科，福建省腹部外科研究所，福州 350005
- Keywords:
Acute liver injury;
Macrophage;
Inflammatory response
- From:
Chinese Journal of Microbiology and Immunology
2024;44(9):822-828
- CountryChina
- Language:Chinese
-
Abstract:
Acute liver injury is a kind of acute liver damage induced by a variety of factors. Severe or persistent acute liver injury leads to the development of acute liver failure with a range of complications. The liver is rich in macrophages, including resident macrophages and monocyte-derived macrophages. The polarization of hepatic macrophages, the secretion of inflammatory factors, the activation of inflammasomes, and the interactions between hepatic macrophages and hepatocytes contribute to disease progression. In addition, with in-depth studies of immune cell metabolism, it has been found that metabolic alterations and metabolites of hepatic macrophages play an important role in regulating their activation and differentiation. In this paper, the mechanisms of hepatic macrophages during acute liver injury are reviewed.
