Influence of cell metabolism on virus-host interaction
10.3760/cma.j.cn112309-20231116-00136
- VernacularTitle:细胞代谢在病毒与宿主互作中的作用
- Author:
Xiaohui WANG
1
;
Yuyu JIANG
;
Yingying DING
;
Xingguang LIU
Author Information
1. 上海理工大学健康科学与工程学院，上海 200093
- Keywords:
Cell metabolism;
Viral replication;
Antiviral responses;
Virus-host interaction
- From:
Chinese Journal of Microbiology and Immunology
2024;44(9):814-821
- CountryChina
- Language:Chinese
-
Abstract:
Cell metabolism is one of the basic characteristics of life, and the host metabolic state is closely related to the process and outcome of viral infection. Viruses can use the metabolites in host cells to complete the life cycle. When the virus particles are adsorbed onto the surface of the susceptible cells and enter the cells, a series of biomolecules synthesized by the host cells are involved in the intracellular transport of the virus. Thus, the virus completes its replication cycle and infects more cells. Besides, metabolic reactions and metabolites can regulate the host antiviral responses at various stages of viral infection, thus affecting the outcome of viral infection. Therefore, cell metabolism plays key roles in affecting viral infection and host antiviral responses. In this paper, the effects of cell metabolism on the interaction between viruses and host cells will be described from the six stages of virus replication cycle in vivo.
