Measles virus antibody levels in cord blood of 1 058 newborns in Ankang city of Shaanxi Province
10.3760/cma.j.cn112309-20240312-00084
- VernacularTitle:陕西省安康市1 058例新生儿脐带血麻疹抗体水平调查
- Author:
Chunge WAN
1
;
Xiaoqiang DAI
;
Yanqi LUO
;
Lin XIANG
;
Lei CHEN
;
Yanyan FU
Author Information
1. 陕西省安康市疾病预防控制中心免疫规划科，安康 725000
- Keywords:
Measles;
Antibody level;
Influencing factors;
Neonatal umbilical cord blood
- From:
Chinese Journal of Microbiology and Immunology
2024;44(9):809-813
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the levels of antibody to measles virus in cord blood of newborns in Ankang city, and provide reference for the development of measles prevention and control measures and strategies.Methods:From January to December, 2023, 1 058 pregnant women from 10 county-level general hospitals in Ankang city were recruited in this study. Neonatal umbilical cord blood samples were collected for detecting IgG antibody against measles with ELISA. SPSS 21.0 software was used to analyze the positive rate of antibody to measles virus and the influencing factors.Results:The overall positive rate of IgG antibody to measles virus was 89.22% (944/1 058), and the geometric mean concentration (GMC) was 570.26 mlU/ml. The positive rates of IgG antibody against measles virus in umbilical cord blood of neonates born to women aged ≤20, 21-25, 26-30, 31-35, and ≥36 years old were 91.07% (51/56), 90.27% (232/257), 89.54% (351/392), 88.12% (230/261), and 86.96% (80/92), respectively (χ 2=1.355, P=0.852). Multivariate logistic regression analysis showed that the positive rate of IgG antibody against measles virus in umbilical cord blood samples was higher in neonates with gestational age ≥37 weeks than in those with gestational age <37 weeks [OR (95%CI): 0.403 (0.262-0.622)]. Besides, the positive rate was also higher in newborns with a birth weight of 3.0-3.5 kg than in those with birth weight <3 kg or ≥3.5 kg [OR (95%CI): 0.868 (0.462-1.629), 1.765(1.087-2.865)]. Conclusions:The positive rate and the GMC of IgG antibody to measles virus in neonatal umbilical cord blood decrease with maternal age. It is recommended that women of childbearing age should receive supplementary immunization with measles-containing vaccine before pregnancy.
