Clinical diagnosis and detection of hemolytic crisis caused by anti-tigecycline antibody
10.3760/cma.j.cn112309-20240109-00011
- VernacularTitle:替加环素药物抗体致溶血危象的临床诊断及检测的探索
- Author:
Jingwei LI
1
;
Ting MA
;
Yi HE
;
Hong YUAN
;
Yingchun XIE
;
Liangfeng FAN
;
Qing NIAN
;
Dong XIANG
Author Information
1. 四川省医学科学院·四川省人民医院（电子科技大学附属医院）输血科，成都 610072
- Keywords:
Hemolytic anemia;
Tigecycline;
Anti-drug antibody;
Blood transfusion therapy
- From:
Chinese Journal of Microbiology and Immunology
2024;44(7):614-619
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the laboratory detection methods for immune hemolytic transfusion reactions caused by anti-tigecycline antibody and the clinical diagnosis and treatment of one patient.Methods:The correlation between hemolysis-related laboratory indexes of the patient and the duration of medication was analyzed. Blood samples of the patient were tested using direct anti-human globulin test, free antibody test, and release test. Erythrocyte sensitization method and immune complexome analysis were used to detect the antibody against tigecycline in the serum of the patient. The properties and the titers of anti-tigecycline antibody were analyzed.Results:Anti-tigecycline antibody was found in the patient through the erythrocyte sensitization method and the immune complexome analysis, and the result of the direct anti-human globulin test was positive. The clinical symptoms and physical signs of the patient improved rapidly after withdrawal of tigecycline and blood transfusion. The patient was discharged after 14-day treatment with immunoglobulin and hormone.Conclusions:Tigecycline can cause hemolytic transfusion reactions. Serological tests are essential for the diagnosis of drug-induced hemolytic anemia. Withdrawal of medications and symptomatic treatment should be conduceted immediately when patients develop drug-related hemolytic anemia.
