Progress in the mechanisms of susceptibility to hypervirulent Klebsiella pneumoniae in diabetic patients
10.3760/cma.j.cn112309-20230801-00023
- VernacularTitle:糖尿病患者易感高毒力肺炎克雷伯菌机制的研究进展
- Author:
Lu JIANG
1
;
Ruiying WANG
;
Shuang WEI
;
Xiansheng LIU
Author Information
1. 山西医科大学第三医院（山西白求恩医院，山西医学科学院，同济山西医院）呼吸与危重症医学科，太原 030032
- Keywords:
Hypervirulent Klebsiella pneumoniae;
Diabetes mellitus;
Pathogenesis
- From:
Chinese Journal of Microbiology and Immunology
2024;44(6):560-564
- CountryChina
- Language:Chinese
-
Abstract:
Hypervirulent Klebsiella pneumoniae (hvKP) is a highly virulent variant of Klebsiella pneumoniae and can cause systemic invasive infection. The worldwide prevalence of hvKP infection continues to increase. Diabetic patients, especially those with poor glucose control, are at a higher risk for hvKP infection. The infection of hvKP in diabetic patients is characterized by high incidence, rapid progression and high fatality rate. The mechanisms underlying the susceptibility to hvKP in patients with diabetes include hyperglycemia-induced bacterial translocation, endothelial-epithelial barrier damage, immune evasion, high-load bacteremia, microthrombosis and hvKP carbon/iron metabolism-based regulation of virulence. A thorough understanding of the mechanisms underlying the susceptibility to hvKP in diabetic patients will be great significant to further improve clinical understanding and attention, and provide early prevention and effective diagnosis and treatment. This article summarizes the progress in the mechanisms of susceptibility to hvKP in diabetic patients in recent years.
