Real-world study of hand, foot and mouth disease vaccine

VernacularTitle:手足口病疫苗的真实世界研究
Author: Mengjun LIAO ¹ ; Lingxian QIU ; Lu CHEN ; Yue HUANG ; Shoujie HUANG ; Tong CHENG ; Ting WU
Author Information

1. 厦门大学公共卫生学院，传染病疫苗研发全国重点实验室，翔安创新实验室，厦门　361102
Keywords: Hand, foot and mouth disease; EV71 vaccine; Epidemiological characteristics; Real-world study
From: Chinese Journal of Microbiology and Immunology 2024;44(6):553-559
CountryChina
Language:Chinese
Abstract: Hand, foot and mouth disease (HFMD) is a common infectious disease among children, and has emerged as a substantial global public health concern, particularly in the Asia-Pacific region. It has a serious impact on children′s health and imposes a significant disease burden on families and society. Currently, there are three globally available HFMD vaccines (all of them are EV71 inactivated vaccine), which were first approved and marketed in China in 2016. Real-world studies have shown a decrease in the incidence, severity, and mortality rate of EV71-related HFMD, providing evidence of its effectiveness. Additionally, related data have indicated a significant change in the pathogen spectrum of HFMD in China in the post-vaccine era. This article aims to provide a comprehensive review of the safety, effectiveness and immune-persistence data of EV71 vaccine acquired through real-world studies.