Epidemiological and pathogenic analysis of an imported case of Y serogroup ST167 complex Neisseria meningitidis
10.3760/cma.j.cn112309-20240312-00087
- VernacularTitle:1例Y群ST167型脑膜炎奈瑟菌输入病例的流行病学和病原学分析
- Author:
Zhencui LI
1
;
Rong LI
;
Yanmei FANG
;
Chang ZHANG
;
Xiaoping SHAO
;
Yingliang LIU
;
Meizhen LIU
Author Information
1. 广东省疾病预防控制中心病原微生物检验所，广州 511430
- Keywords:
Neisseria meningitidis;
ST167 clonal complex;
Multilocus sequence typing;
Antibiotic resistance
- From:
Chinese Journal of Microbiology and Immunology
2024;44(6):480-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the pathogen and clinically diagnose for a suspected case of Neisseria meningitidis with positive blood culture result, and assess the risk of disease transmission among the community. Methods:Blood sample was collected for Neisseria meningitidis isolation and culture. Pathogen identification and serogroup typing were conducted by colony morphology, Gram staining, biochemical tests, latex agglutination test, slide agglutination test, and nucleic acid testing. The susceptibility to 12 antibiotics was also tested. Epidemiological investigation was conducted on the case, and epidemic control measures were also implemented. Results:Through various detection, the suspected case was diagnosed as Neisseria meningitidis invasive infection. The isolated strain belonged to group Y serotype, type 767 (multilocus sequence typing), and the ST167 clonal complex. The strain was sensitive to nine antibiotics, including penicillin, ampicillin, and meropenem. It exhibited intermediate sensitivity to ciprofloxacin and levofloxacin, and resistance to methicillin/sulfamethoxazole. Close contacts of the case and environmental testing results were negative. Conclusions:The case is confirmed to be an invasive infection caused by group Y Neisseria meningitidis, the ST167 clonal complex. Epidemiological investigation shows a relatively low risk of epidemic transmission. Continuous monitoring and surveillance are necessary for further assessment.
