Mast cell-derived exosomes and intercellular communication between immune cells mediated by them
10.3760/cma.j.cn112309-20230322-00069
- VernacularTitle:肥大细胞外泌体及其介导的免疫细胞间通讯
- Author:
Bingqi ZHANG
1
;
Yueshan SUN
;
Mingcai ZHAO
;
Yuanbiao GUO
Author Information
1. 西南交通大学医学院，西南交通大学附属医院/成都市第三人民医院实验医学部，成都 610031
- Keywords:
Mast cell;
Exosome;
Dendritic cell;
T cell;
Macrophage
- From:
Chinese Journal of Microbiology and Immunology
2024;44(5):468-472
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are a subpopulation of extracellular vesicles ranging in size from 30 to 150 nm. They contain a variety of biological molecules including proteins, lipids, and genetic materials by which they can act as mediators of cell-to-cell communication. Increasing studies on exosomes have elucidate the mechanism of communication between immune cells. Mast cells are found to release exosomes in both resting and activated states, but the quantity, contents and functions of the exosomes are significantly different in different states. Mast cell-derived exosomes are involved in the maturation and antigen presentation of dendritic cells, and mediate the activation of T lymphocytes and the polarization of macrophages. These results provide new insights into the role of exosomes in mast cell function and immune regulation.
