The cGAS-STING pathway: a potential therapeutic target for rheumatoid arthritis
10.3760/cma.j.cn112309-20230830-00059
- VernacularTitle:cGAS-STING信号通路：类风湿关节炎的潜在治疗靶点
- Author:
Ronghui SU
1
;
Liyun CHENG
;
Xiaoyu ZI
;
Hui WANG
;
Xiaofeng LI
;
Caihong WANG
Author Information
1. 山西医科大学第二医院风湿免疫科，太原 030001
- Keywords:
cGAS-STING signaling pathway;
Rheumatoid arthritis;
TypeⅠ interferon;
Cytoplasmic DNA receptor
- From:
Chinese Journal of Microbiology and Immunology
2024;44(5):460-467
- CountryChina
- Language:Chinese
-
Abstract:
Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) pathway, as an important part of the innate immune system, is the main pathway for cytoplasmic DNA recognition and cGAS can be triggered by a variety of cytoplasmic dsDNA. This pathway has become an important bridge connecting autoimmunity, aseptic inflammatory response and cell aging. In recent years, cGAS-STING pathway has attracted increasing attention in autoimmune diseases. In rheumatoid arthritis (RA), neutrophil extracellular traps (NETs) induce typeⅠ interferon response and accelerate the production of anti-citrullinated peptide antibody (ACPA) through the cGAS-STING pathway. In addition, the cGAS-STING pathway also participates in synovitis, bone destruction and RA progression by promoting the proliferation and activation of fibroblast-like synovitis cells and the polarization of M1 macrophages. Inhibition of the cGAS-STING pathway or its downstream signaling pathway can reduce synovial inflammation in RA, suggesting that cGAS-STING pathway may be a potential therapeutic target for RA.
