Progress in the roles of RNA and post-translational modifications in enterovirus infection and pathogenesis

VernacularTitle:RNA及翻译后修饰在肠道病毒感染与致病中的研究进展
Author: Xiaoling XUE ¹ ; Zhen LUO ; Yuya WANG ; Bangtao CHEN ; Xiaoli TAO
Author Information

1. 锦州医科大学基础医学院病原生物学系，锦州　121001
Keywords: Enterovirus; RNA modification; Protein post-translational modification
From: Chinese Journal of Microbiology and Immunology 2024;44(5):453-459
CountryChina
Language:Chinese
Abstract: Enterovirus (EV) includes a group of important RNA viruses with similarity in viral structure and pathogenesis. They can cause various diseases in humans and pose a great threat to human health. The biological events that occur in EV-host interactions are the core topics to be investigated for better understanding the pathogenesis of EV and developing related prevention and treatment strategies. With the development of genomics technologies, RNA modifications and protein post-translational modifications (PTM) in EV and its hosts have drawn much attention and some achievements have been made, which may shed light on developing precise strategies for the prevention and control of EV-associated diseases. In this paper, to better understand the pathogenesis of EV infection and provide reference for clinical translational research, the progress in the roles of RNA modifications and protein PTM in EV-host interactions are summarized.