Progress in the regulation of Th17/Treg immune balance by estrogen in systemic lupus erythematosus
10.3760/cma.j.cn112309-20230613-00168
- VernacularTitle:系统性红斑狼疮中雌激素调控Th17/Treg免疫平衡的研究进展
- Author:
Hui WANG
1
;
Dongming WANG
;
Rui SU
;
Xiaoyu ZI
;
Ronghui SU
;
Xiaofeng LI
;
Caihong WANG
Author Information
1. 山西医科大学第二医院风湿免疫科，太原 030001
- Keywords:
Systemic lupus erythematosus;
Th17/Treg immune balance;
Estrogen;
Intestinal microbiota
- From:
Chinese Journal of Microbiology and Immunology
2024;44(5):447-452
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus (SLE) shows a significant gender difference. In addition to X chromosome inactivation (XCI) abnormalities, which may lead to the gender difference in SLE, studies have found that estrogen plays a key role in regulating Th17/Treg immune balance in SLE. Estrogen indirectly affects the quantity and function of Th17 and Treg cells by acting on B cells. In this process, the mutual influence and the interaction between B and T cells promote the development of SLE. Recent studies have reported gender differences in intestinal microbiota, which may lead to sex-dependent genetic susceptibility and epigenetic changes in autoimmune diseases represented by SLE. The interaction between estrogen and intestinal microbiota in SLE affects the immune balance of Th17/Treg cells. This paper mainly reviews the way estrogen works, and the mechanisms by which estrogen regulates Th17/Treg immune balance and the interaction between B and T cells in SLE, hoping to provide new targets for new therapeutic strategies such as selective estrogen receptor modulators.
