Progress in human leukocyte antigen G in the progression of COVID-19
10.3760/cma.j.cn112309-20231229-00195
- VernacularTitle:人类白细胞抗原G与COVID-19研究进展
- Author:
Aifen LIN
1
;
Weihua YAN
Author Information
1. 温州医科大学附属台州医院生物资源中心，台州 317000
- Keywords:
Human leucocyte antigen G;
SARS-CoV-2;
COVID-19;
Immune response;
Susceptibility
- From:
Chinese Journal of Microbiology and Immunology
2024;44(5):441-446
- CountryChina
- Language:Chinese
-
Abstract:
Host immune response to viruses is critical for virus clearance and disease control. Dramatically decreased numbers and exhaustion of immune cells are common in COVID-19 patients, which is found to be closely related to the severity of the disease and poor prognosis. Human leukocyte antigen G (HLA-G) is an important immune checkpoint that can specifically bind to various immunosuppressive receptors expressed by immune cells, and systematically suppress the host immune response. Recent studies have shown that HLA-G gene polymorphism and its expression are of great significance for susceptibility to SARS-CoV-2 and the progression of COVID-19. In this review, the genetic and molecular characteristics of HLA-G, HLA-G/receptor signaling and immune function regulation, and its clinical significance in COVID-19 progression are summarized.
