The effects of transcranial direct current stimulation on the picture naming of aphasic stroke survivors as studied by fMRI
10.3760/cma.j.cn421666-20220523-00557
- VernacularTitle:静息态功能磁共振观察经颅直流电刺激对脑卒中后图片命名功能障碍的影响
- Author:
Xiaoxuan WANG
1
;
Yancheng SONG
;
Yanlong YANG
;
Liqing KANG
;
Min SUN
;
Meng ZHAO
;
Shan LU
Author Information
1. 沧州市中心医院磁共振成像科，沧州 061000
- Keywords:
Aphasia;
Resting-state imaging;
Functional magnetic resonance imaging;
Magnetic resonance amplitude fluctuations;
Brain region homogeneity;
Transcranial di
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2024;46(11):973-979
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To document any effect of transcranial direct current stimulation (tDCS) on the picture naming ability of stroke survivors with aphasia.Methods:Twenty-eight aphasic stoke survivors with picture naming dysfunction were divided into an acute group (with a course of disease of <1 month) and a convalescent group (with a course of disease of 2 to 6 months). Eighteen healthy subjects well-matched for age, gender and years of education formed the healthy control group. The patient group received tDCS once a day, 5 days a week for 2 weeks. Before and after the intervention, they were assessed using the Chinese psycholinguistic aphasia assessment (PACA) instrument. The activation of speech-related brain areas in everyone was quantified using resting state functional magnetic imaging (rs-fMRI).Results:After treatment the average PACA image naming scores of both the acute and convalescent groups had improved significantly. ALFF showed significant positive activation in the patient group′s right inferior temporal gyrus and negative activation in their left posterior central gyrus, while ReHo was significantly and positively activated in the right orbital superior frontal gyrus, the left medial superior frontal gyrus, the pericalar fissure cortex and the left parietal gyrus. It was, however, significantly negatively activated in the right posterior central gyrus. In the acute stage group, the ALFF was significantly and positively activated in the right superior frontal gyrus and right angular gyrus after the treatment, while the significant positive ReHo activation was in the right direct gyrus, the right angular gyrus, the right superior frontal gyrus and the right inferior temporal gyrus. In the convalescent group after the intervention the ALFF was significantly and positively activated in the left middle occipital gyrus and the right fusiform gyrus but negatively and significantly activated in the right insula, while ReHo was significantly and positively activated in the left superior temporal gyrus and the right angular gyrus.Conclusions:tDCS can improve the image naming of aphasic stroke survivors. The compensatory activation of language function is mainly in the right hemisphere in the acute stage, but in the convalescent stage the unimpaired brain area of the left cerebral hemisphere is also activated. The long-term recovery of language functioning may be the result of synergy between the hemispheres.
