Combining ultrasound with balloon-guided injection of botulinum toxin in the treatment of cricopharyngeal achalasia
10.3760/cma.j.issn.0254-1424.2024.10.006
- VernacularTitle:超声联合球囊引导下注射肉毒毒素治疗环咽肌失弛缓症的疗效观察
- Author:
Yuli ZHU
1
;
Yi LI
;
Qiongshuai ZHANG
;
Heping LI
;
Hongji ZENG
;
Jing ZENG
;
Dejun ZHU
;
Xueyun MA
;
Xi ZENG
;
Liugen WANG
Author Information
1. 郑州大学第一附属医院康复医学科，郑州 450000
- Keywords:
Dysphagia;
Cricopharyngeal achalasia;
Botulinum toxin;
Ultrasound;
Balloon dilation
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2024;46(10):898-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe any clinical effect of supplementing ultrasound stimulation with balloon-guided injection of botulinum toxin into the upper esophageal sphincter in the treatment of cricopharyngeal achalasia.Methods:Forty patients with cricopharyngeal achalasia were randomly divided into an observation group and a control group, each of 20. Both groups were given routine swallowing rehabilitation training, while the observation group additionally had botulinum toxin injected into the upper esophageal sphincter guided by ultrasound and with the aid of balloon dilation. Before the experiment and after 2 weeks, both groups were evaluated videofluoroscopically and flexible endoscopic evaluation of swallowing was performed. Moreover, 2 weeks before the treatment and 2, 4 and 24 weeks afterward, everyone′s eating, leakage and aspiration, and oral and pharyngeal secretions were assessed using the functional oral intake scale (FOIS), the penetration-aspiration scale (PAS), the fiberoptic endoscopic dysphagia severity scale (FEDSS) and the Murray secretion scale (MSS).Results:After 2 weeks the average PAS, FEDSS and MSS scores of both groups had improved significantly, but the observation group′s averages[3(2, 5), 3(2, 5) and 2(1, 2)] were significantly better than those of the control group. 2, 4 and 24 weeks after the experiment the average FOIS scores of both groups also showed significant improvement, with the observation group′s average[3(2, 4), 4(2, 6) and 6(3, 7)] again significantly better than that of the control group.Conclusions:A botulinum toxin injection into the upper esophageal sphincter can effectively improve the swallowing of persons with cricopharyngeal achalasia with adequate safety and significant long-term benefits. Therefore, such treatment is worthy of clinical promotion and application.
