Clinical features and risk factors for comorbid epilepsy among preschool children with cerebral palsy
10.3760/cma.j.issn.0254-1424.2024.08.008
- VernacularTitle:学龄前脑性瘫痪儿童共患癫痫的临床特征和危险因素分析
- Author:
Jingli ZHANG
1
;
Rong REN
;
Mei HOU
;
Aiyun YUAN
Author Information
1. 青岛大学附属妇女儿童医院康复科，青岛 266034
- Keywords:
Cerebral palsy;
Epilepsy;
Preschool children;
Gross motor function classification;
Cranial magnetic resonance classification
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2024;46(8):716-721
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the etiology and typology of cerebral palsy (CP) in preschool children with comorbid epilepsy, and their gross motor function (GMFCS) and cranial magnetic resonance (MRICS) classifications.Methods:A total of 837 children (aged 6 months to 6 years) hospitalized with cerebral palsy were divided into an epileptic group ( n=174) and a non-epileptic group ( n=663). Their general data, CP type, CP etiology, GMFCS classifications, MRICS classifications and Gesell development scores were analyzed. Results:Among the 174 children with epilepsy, 158 (90.8%) were under 3 years old. The most common type of CP in the epilepsy group was spastic quadriplegia (50.0%). In the non-epilepsy group it was spastic diplegia (42.1%), a significant difference. There were also significant differences between the two groups in terms of etiology. The number of cases of abnormal brain development differed significantly, as did genetic factors and history of asphyxia. There were also significant differences between the two groups in terms of GMFCS classifications and the distribution of MRICS classes. In the epileptic group, the proportion of gray matter injury was 31.6%. However, white matter injury ranked first in both the epileptic group and the non-epileptic group, reaching 40.8% and 53.7%, respectively. In terms of cognitive functioning there were significant differences in the groups′ mean Gesell developmental quotients: epileptic group 52.21 and non-epileptic group 70.59.Conclusions:The clinical characteristics of CP children with comorbid epilepsy differ with age, CP cause and type, as well as GMFCS and MRICS classifications. Children less than 3 years old with brain mal-developments and genetic factors or asphyxia-hypoxia etiology mostly display spastic quadriplegia CP. They mainly suffer from gray matter injury. The higher the GMFCS classification, the greater the proportion of CP with co-occurring epilepsy and the more severe the cognitive lag tends to be.
