Propionic and butyric acid levels can predict ability in the activities of daily living after an ischemic stroke
10.3760/cma.j.issn.0254-1424.2024.07.010
- VernacularTitle:短链脂肪酸与缺血性脑卒中患者日常生活活动能力的相关性研究
- Author:
Hankui YIN
1
;
Zhongli WANG
;
Ming ZENG
;
Ming SHI
;
Yun REN
;
Linhua TAO
;
Yunhai YAO
;
Jianming FU
;
Xudong GU
Author Information
1. 浙江嘉兴市第二医院康复医学中心，嘉兴 314000
- Keywords:
Ischemia;
Stroke;
Activities of daily living;
Short-chain fatty acids;
Butyric acid;
Propionic acid
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2024;46(7):631-634
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To seek a correlation between short-chain fatty acids (SCFAs) and skill in the activities of daily living (ADL) after an ischemic stroke.Methods:Ninety ischemic stroke survivors were assessed using the Barthel Index (BI). Fecal samples were collected and analyzed for the concentration of acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, and isovaleric acid using gas chromatography. Spearman correlation analysis was conducted to identify SCFAs that correlated with the total BI score. Linear regressions were evaluated to explore the correlation between the total BI score and SCFAs.Results:The concentrations of propionic and butyric acids in the feces were found to correlate significantly with the total BI scores. Data including propionic acid and butyric acid levels, age, gender, body mass index, disease duration, any history of hypertension or diabetes, and other SCFAs were included in the regression models. Propionic and butyric acid levels were found to be potentially useful predictors of total BI scores.Conclusions:The concentration of propionic and butyric acids in the feces after an ischemic stroke can predict the survivor′s total BI score. Those concentrations could therefore be useful for predicting ADL ability.
