Role of mitochondrial DNA and its mediated inflammatory damage in kidney diseases
10.3760/cma.j.cn441217-20240130-00142
- VernacularTitle:线粒体DNA及其介导的炎症损伤在肾脏疾病中的作用
- Author:
Houhui JIANG
1
;
Zhongping WEI
;
Zhaowei CHEN
;
Guohua DING
Author Information
1. 武汉大学人民医院肾内科，武汉 430060
- Keywords:
Renal disease;
DNA, mitochondrial;
Mitochondria;
Inflammation
- From:
Chinese Journal of Nephrology
2024;40(10):840-845
- CountryChina
- Language:Chinese
-
Abstract:
Kidney is a highly energy-demanding organ rich in mitochondria. Numerous studies have indicated that mitochondria play a crucial role in maintaining normal kidney function and in the pathogenesis of various kidney diseases. Mitochondrial DNA is the exclusive genome of mitochondria. Damage to mtDNA not only leads to mitochondrial dysfunction and degradation of mitochondrial quality, but also acts as an endogenous inflammatory molecule, activating various inflammatory pathways, which contribute to cellular damage and the progression of kidney diseases. This article reviews the mechanisms of mitochondrial DNA damage and its significant role in triggering inflammatory injury in kidney diseases. Additionally, it summarizes the current research progress on various intervention strategies targeting this type of damage.
