Urinary RNA oxidation as a potential predictive biomarker for postoperative acute kidney injury in thoracic surgery patients

VernacularTitle:尿RNA氧化产物水平预测胸外科手术患者术后急性肾损伤的价值
Author: Lengnan XU ¹ ; Ban ZHAO ; Qinghua WENG ; Aiqun CHEN ; Ying SUN ; Jianping CAI ; Yonghui MAO
Author Information

1. 北京医院肾内科　国家老年医学中心　中国医学科学院老年医学研究院，北京　100730
Keywords: Oxidative stress; Acute kidney injury; Perioperative period; 8-Hydroxy-2'-deoxyguanosine; Postoperative complications
From: Chinese Journal of Nephrology 2024;40(10):811-814
CountryChina
Language:Chinese
Abstract: Oxidative stress plays a key role in acute kidney injury (AKI). 8-Oxo-7,8-dihydroguanosine (8-oxo-Gsn) can reflect the overall level of oxidative stress in the body. The levels of urinary 8-oxo-Gsn and renal function-related indicators in 62 patients who underwent video-assisted thoracic surgery (VATS) or open-chest surgery were measured during the perioperative period. The results showed that urinary 8-oxo-Gsn increased 24 hours after surgery and decreased 48 hours after surgery as the condition improved. In 10 patients with severe complications, urinary 8-oxo-Gsn continued to rise. The level of urinary 8-oxo-Gsn in the VATS group recovered faster than that in the open-chest surgery group ( P<0.05). There was a certain correlation between the level of urinary 8-oxo-Gsn and postoperative renal injury in thoracic surgery, suggesting that RNA oxidative stress may play an important role in the pathogenesis of surgery-related AKI.