Microbiological characteristics and treatment outcome analysis of exit-site infection in peritoneal dialysis patients
10.3760/cma.j.cn441217-20240429-00443
- VernacularTitle:腹膜透析患者导管出口感染的微生物特征及治疗转归分析
- Author:
Danyang LIU
1
;
Guangqing ZHANG
;
Lu ZHU
;
Xiaohong ZHONG
;
Tingting ZHANG
;
Yanhong LIN
;
Jianping JIANG
;
Yan LU
;
Nirong GONG
Author Information
1. 南方医科大学南方医院肾内科，广州 510515
- Keywords:
Peritoneal dialysis;
Infections;
Bacterial infections;
Microbial sensitivity tests
- From:
Chinese Journal of Nephrology
2024;40(10):798-803
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe the incidence of peritoneal dialysis (PD) catheter exit site infection (ESI) and to analyze its pathogenic bacteria characteristics.Methods:The clinical data of PD patients with ESI in Nanfang Hospital of Southern Medical University from 2020 to 2022 was reviewed to describe the dynamic changes in the incidence of ESI, and to analyze the distribution of ESI pathogens, antimicrobial sensitivity analysis of topical antibiotics and treatment outcomes.Results:A total of 187 ESI episodes occurred in 159 PD patients. The proportion of gram-positive and gram-negative ESI were 80.7% and 18.3%, respectively. The main gram-positive and gram-negative pathogen were coagulase negative Staphylococcus (51.1%) and Pseudomonas aeruginosa (60.0%). Rifampicin (sensitivity rate of gram-positive organisms was 88.9%; gram-negative organisms was 100.0%) and gentamicin (sensitivity rate of gram-positive organisms was 83.6%; gram-negative organisms was 93.3%) is the main topical sensitive antibiotics. 137 cases (73.3%) of ESI were cured within 2 weeks after treatment. Among the 50 cases (26.7%) of refractory ESI, 22.0% of cases were associated with tunnel infection, 10.0% with tunnel reconstruction, and only 4.0% with removal of PD catheter. Conclusion:Monitoring and reporting of ESI is an important part to improve the quality of PD management. By reviewing the incidence of ESI, pathogenic bacteria characteristics and treatment effects, real and reliable observational data for the formulation of relevant guidelines and clinical diagnosis and treatment can be provided.
