Research advances of membranous nephropathy-associated antigens
10.3760/cma.j.cn441217-20230815-00820
- VernacularTitle:膜性肾病相关抗原的研究进展
- Author:
Yifeng WANG
1
;
Ruiying CHEN
;
Qionghong XIE
;
Chuanming HAO
Author Information
1. 复旦大学附属华山医院肾病科，上海 200040
- Keywords:
Membranous nephropathy;
Antigens;
Phospholipase A2 receptor
- From:
Chinese Journal of Nephrology
2024;40(7):565-572
- CountryChina
- Language:Chinese
-
Abstract:
The identification of pathogenic antigens in membranous nephropathy (MN) is a hot topic in the research field of kidney diseases. In recent years, the widespread application of mass spectrometry has brought a breakthrough in the identification of MN-pathogenic antigens. As the antigen spectrum continues to be refined, the diagnosis of MN has evolved from morphological level to molecular level. This article reviewed the research progress of currently identified antigens of MN, such as phospholipase A2 receptor (a major pathogenic antigen of primary MN), thrombospondin type 1 domain-containing 7A (a potential tumor-associated antigen), neural epidermal growth factor-like protein 1 (an antigen associated with various secondary factors), semaphorin 3B (an antigen specific to pediatric MN) and so on, and the pathogenic mechanisms and clinical significance of these antigens.
