Researches progress on the pathogenesis mechanism of ferroptosis and pharmacotherapy in kidney diseases

VernacularTitle:肾脏病中铁死亡的病理生理机制和药物疗法研究进展
Author: Weijing LAI ¹ ; Rongshuang HUANG ; Bo WANG ; Ping FU ; Liang MA
Author Information

1. 成都医学院第一附属医院肾病科，成都　610500
Keywords: Ferroptosis; Kidney diseases; Drug therapy; Mechanism
From: Chinese Journal of Nephrology 2024;40(5):411-417
CountryChina
Language:Chinese
Abstract: Ferroptosis is an iron-dependent programmed cell death. Iron overload and lipid reactive oxygen accumulation play a core role in the occurrence and development of ferroptosis. Any factors affecting the balance of iron metabolism and redox system may induce and aggravate ferroptosis. Ferroptosis is involved in the pathological process of acute kidney injury, diabetic nephropathy, renal interstitial fibrosis and some other kidney diseases, and inhibiting ferroptosis has potential renoprotective benefits. This article reviewed the pathophysiological mechanism of ferroptosis and its research progress in renal diseases, and discussed the application prospect of targeted ferroptosis in the treatment of renal diseases.