Allogeneic hematopoietic stem cell transplantation complicated with protocadherin FAT1-associated membranous nephropathy: a case report
10.3760/cma.j.cn441217-20230823-00833
- VernacularTitle:异基因造血干细胞移植后合并原钙黏蛋白FAT1相关膜性肾病1例
- Author:
Lin WANG
1
;
Shuling YUE
;
Jianjing HE
;
Xuhui SHE
;
Liping JIE
;
Enfeng LU
Author Information
1. 广州金域医学检验中心病理科，广州510320
- Keywords:
Kidney Diseases;
Hematopoietic stem cell transplantation;
Glomerulonephritis, membranous;
Allogeneic hematopoietic stem cell transplantation;
FAT1
- From:
Chinese Journal of Nephrology
2024;40(5):400-402
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietic stem cell transplantation is an effective method for treating various hematological diseases. Membranous nephropathy is the second leading cause of novo glomerular disease after transplantation. Protocadherin FAT1 is a target antigen for diagnosing membranous nephropathy, primarily related to hematopoietic stem cell transplantation. Here we report a rare case of membranous nephropathy after hematopoietic stem cell transplantation. The target antigen of membranous nephropathy was confirmed to be FAT1 by pathology combined with mass spectrometry analysis. The nephrotic syndrome achieved partial remission after corticosteroid combined with cyclosporine treatment, and the patient's condition was stable during follow-up.
