Recent advance in role of microglia in neuroinflammation regulation and disease treatment after traumatic brain injury

VernacularTitle:小胶质细胞在创伤性颅脑损伤后神经炎症调控及疾病治疗中的研究进展
Author: Huiting ZHAO ¹ ; Junlong ZHAO ; Sanzhong LI ; Hongyan QIN ; Mingtao MU
Author Information

1. 延安大学基础医学院，延安　716000
Keywords: Traumatic brain injury; Microglia; Treatment; Inflammation
From: Chinese Journal of Neuromedicine 2024;23(11):1179-1187
CountryChina
Language:Chinese
Abstract: Traumatic brain injury (TBI) can cause a series of secondary changes, such as neuronal dysfunction, blood-brain barrier destruction, secondary neurovascular injury, neuroinflammation, and even neurodegenerative diseases. In recent years, studies have found that microglia can regulate the long-term inflammation and tissue repair process after TBI through the changes of M1 phenotype and M2 phenotype, affecting the TBI progress. Therefore, this article reviews the recent advance in role of microglia, regulatory mechanisms and related therapies of microglia after TBI, in order to provide some references for TBI treatment.