Recent advance in role of resolvin D1 in inflammatory injury of major neurological diseases
10.3760/cma.j.cn115354-20240817-00493
- VernacularTitle:消退素D1在重大神经系统疾病炎症损伤中的作用研究进展
- Author:
Xiaoyu LYU
1
;
Ziyou ZHANG
;
Zhuang LI
;
Dandan LI
;
Mingrui LIU
;
Yangyang ZHONG
;
Yusong HE
;
Yannan SHAO
;
Yan YU
;
Bensi ZHANG
Author Information
1. 大理大学基础医学院，大理 671003
- Keywords:
Resolvin D1;
Inflammation;
Nervous system disease
- From:
Chinese Journal of Neuromedicine
2024;23(11):1172-1178
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are often associated with inflammatory mechanisms, where persistent or excessive inflammatory responses can lead to neuronal damage and subsequent pathological changes. In acute neurological conditions such as stroke or traumatic brain injury, inflammation is a key factor that triggers acute neuronal injury and long-term sequelae. In chronic neurodegenerative diseases, including Alzheimer's disease, cognitive dysfunction, Parkinson's disease, and multiple sclerosis, the chronic activation of inflammation is closely related to gradual degeneration of neurons. Resolvin D1 (RvD1), an endogenous pro-resolving mediator, plays a crucial role in controlling the intensity and duration of inflammation by inhibiting excessive activation of immune cells, modulating the release of pro-inflammatory cytokines, and maintaining the integrity of the blood-brain barrier. This review focuses on the mechanisms of RvD1 in mediating inflammatory damage in major neurological diseases, aiming to provide theoretical support for a deeper understanding of disease mechanism, optimized therapeutic strategies, and enhanced outcome.
