Recent advance in myelin injury and pro-myelin remodeling in improving cognitive dysfunction
10.3760/cma.j.cn115354-20240731-00437
- VernacularTitle:髓鞘损伤及促髓鞘重塑治疗在改善认知功能障碍中的研究进展
- Author:
Wenxiu LI
1
;
Xiang TANG
;
Jianhua JIANG
Author Information
1. 苏州大学附属第一医院神经内科，苏州 215006
- Keywords:
Cognitive dysfunction;
Myelin;
Pro-myelin remodeling
- From:
Chinese Journal of Neuromedicine
2024;23(11):1167-1171
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive dysfunction often coexists with age-related neurodegenerative diseases, leading to decline in the quality of life of individuals and bringing burden on families and society. Myelin sheath is one of the important structures of neurons, and myelin damage can be seen in patients with cognitive dysfunction resulting from neurodegenerative diseases. Early intervention of myelin damage, such as promoting OLs differentiation and miRNA-based therapy, can help pro-myelin remodeling, thereby improve cognitive dysfunction and reduce incidence of cognitive dysfunction in neurodegenerative diseases. This article reviews the recent advance in relationship between myelin injury and cognitive function, and pro-myelin remodeling in improveing cognitive dysfunction, in order to provide references for treatment of cognitive dysfunction.
