New insights into pathogenesis, diagnosis and treatment of Alzheimer's disease based on APOE ε4 allele
10.3760/cma.j.cn115354-20240816-00492
- VernacularTitle:基于 APOE ?4等位基因分型的阿尔茨海默病发病机制及诊疗研究新视角
- Author:
Hui LIANG
1
;
Jiyi XU
;
Huolan WEI
;
Bin QIN
Author Information
1. 海南省人民医院（海南医科大学附属海南医院）神经内科，海南省临床医学中心，海口 570311
- Keywords:
Alzheimer's disease;
Probabilistic apolipoprotein E hypothesis;
Apolipoprotein E ε4 allele
- From:
Chinese Journal of Neuromedicine
2024;23(11):1155-1159
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, it has been found that complex pathological manifestations of Alzheimer's disease (AD) cannot be fully explained by β-amyloid (Aβ) cascade hypothesis, and researchers question this hypothesis resulting from the poor effect of targeted Aβ drugs. Probabilistic apolipoprotein E (APOE) hypothesis affirms the Aβ pathogenesis but also emphasizes the important role of APOE gene in diagnosis, treatment and progression of AD. In AD diagnosis, subjects should be firstly grouped according to presence or absence of APOE ε4 allele, and then classified according to Aβ deposition/tau neurofibrillary tangles/neurodegeneration. This article reviews the recent advance in the pathogenesis, diagnosis and treatment of 3 types of AD variants (autosomal dominant AD, sporadic AD related to APOE ε4, and sporadic AD unrelated to APOE ε4), with a view to understand the importance of APOE ε4 allele in AD from a new perspective.
