Recent advance in heterogeneous manifestations of pituitary adenomas and their clinical significance
10.3760/cma.j.cn115354-20240901-00527
- VernacularTitle:垂体腺瘤异质性表现及其临床意义的研究进展
- Author:
Shaoyong LIN
1
;
Yuhui CHEN
;
Jun LI
;
Shousen WANG
Author Information
1. 福建医科大学福总临床医学院（第九〇〇医院）神经外科，福州 350025
- Keywords:
Pituitary adenomas;
Heterogeneity;
Imaging;
Pathology;
Molecular biology
- From:
Chinese Journal of Neuromedicine
2024;23(10):1064-1068
- CountryChina
- Language:Chinese
-
Abstract:
Tumor heterogeneity is one of the characteristics of malignant tumors, which refers to the molecular biology or genetic changes in the daughter cells of tumors after multiple division and proliferation during the growth process, resulting in changes in tumor growth rate, invasion ability, drug sensitivity, and prognoses. Pituitary adenomas (PAs) are generally considered as benign tumors without obvious heterogeneity, but the identification of reliable heterogeneity markers still plays a key role in clinical diagnosis and treatment. In clinical practice, the heterogeneity of parenchymal PAs includes differences in imaging findings, histopathological findings, and molecular information. This article reviews the research results in PAs heterogeneity so as to provide better enlightenment for clinical research and practice.
