Recent advance in clinical trials and animal experiments regarding teratogenic effects of anti-seizure medication
10.3760/cma.j.cn115354-20240625-00378
- VernacularTitle:抗癫痫发作药物致畸的临床试验和动物实验研究进展
- Author:
Qiulei HONG
1
;
Yifei DUAN
;
Leihao SHA
;
Yilin XIA
;
Yusha TANG
;
Lei CHEN
Author Information
1. 四川大学华西医院神经内科，成都 610041
- Keywords:
Epilepsy;
Anti-seizure medication;
Pregnancy;
Drug safety;
Teratogenesis
- From:
Chinese Journal of Neuromedicine
2024;23(9):940-946
- CountryChina
- Language:Chinese
-
Abstract:
Pregnant women account for 40% of all epilepsy patients, and the economic burden of pregnant women with epilepsy is 5 times higher than that of non-pregnant patients. Additionally, the rates of stillbirth and congenital malformations in pregnant women with epilepsy are 5 times greater than those in normal pregnant women. Therefore, it is crucial to comprehensively review and summarize the management of pregnant women with epilepsy to reduce the burden of the disease. This study provides a thorough review on teratogenic effects of anti-seizure medications (ASMs) used during pregnancy, and summarizes the effects of ASMs on health of offspring and offers clinical management recommendations for pregnant women with epilepsy, aiming to provide guidance for safe use of medications during pregnancy.
