Recent advance in Aβ tolerance in Alzheimer's disease
10.3760/cma.j.cn115354-20240617-00353
- VernacularTitle:β-淀粉样蛋白耐受在阿尔茨海默病中的研究进展
- Author:
Jiayue CHEN
1
;
Xueyan HUANG
;
Qianqian YAO
;
Changyin YU
Author Information
1. 遵义医科大学附属医院神经内科，遵义 563000
- Keywords:
Alzheimer's disease;
Beta-amyloid;
Resilience;
Reserve
- From:
Chinese Journal of Neuromedicine
2024;23(8):837-841
- CountryChina
- Language:Chinese
-
Abstract:
Beta-amyloid (Aβ) is considered to be a central event in Alzheimer's disease (AD). However, it has been found that some population have Aβ deposition in the brain and even AD related pathology without obvious cognitive impairment, which indicates that there are factors in the body to avoid or cope with Aβ damage, and this phenomenon is called Aβ tolerance. Starting from the concepts of resilience and reserve, this paper intends to sort out the epidemiology and quantitative methods, brain characteristics and influencing factors of Aβ tolerance, in order to further deepen clinicians' understanding of Aβ tolerance in AD diagnosis and treatment, so as to provide new ideas for prevention and treatment of the disease.
