Recent advance in neuroimaging abnormal changes of brain regions associated with mild cognitive impairment

VernacularTitle:轻度认知障碍相关脑区影像学异常改变的研究进展
Author: Shuyuan LYU ¹ ; Xitong ZHANG ; Zhaohui GUO ; Shaodong CAO ; Yongnan LI
Author Information

1. 哈尔滨医科大学附属第四医院神经内科，哈尔滨　150001
Keywords: Mild cognitive impairment; Brain region; Neuroimaging marker
From: Chinese Journal of Neuromedicine 2024;23(6):644-648
CountryChina
Language:Chinese
Abstract: Mild cognitive impairment (MCI) is the transitional stage between healthy aging and dementia, enjoying high risk of progression to Alzheimer's disease (AD). Therefore, MCI stage becomes the most important node for early identification, diagnosis and prevention of AD. At present, MCI clinical diagnosis lacks neuroimaging markers with non-invasive, timely and economic advantages. Recent studies suggest that microstructural and/or functional changes may occur in brain regions such as the hippocampus, amygdala, cingulate gyrus, thalamus, putamen, caudate nucleus and corpus callosum during MCI stage, and imaging features of these abnormal changes may serve as neuroimaging markers for early diagnosis of MCI. This article reviews the research progress on the abnormal changes of MCI related brain regions in neuroimaging.