Recent advance in diagnosis, treatment and pathogenesis of Parkinson's disease comorbid depression and anxiety
10.3760/cma.j.cn115354-20240507-00278
- VernacularTitle:帕金森病合并抑郁、焦虑的诊治及发病机制研究进展
- Author:
Chenxi SUN
1
;
Zihao ZHANG
;
Huiqing WANG
;
Baohua CHENG
Author Information
1. 济宁医学院临床医学院，济宁 272067
- Keywords:
Parkinson's disease;
Depression;
Anxiety
- From:
Chinese Journal of Neuromedicine
2024;23(6):631-637
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is a kind of neurodegenerative disease based on damage of striatal nigrostriatal dopaminergic neurons, with motor dysfunction as typical clinical feature. However, PD is often accompanied by a series of non-motor symptoms (NMS) represented by depression and anxiety, which not only interferes with clinical management of PD patients, but also seriously affects quality of life of patients. Pathophysiological mechanism of PD comorbid depression and anxiety is still unclear, but is closely related to the disease process, severity of motor dysfunction, and metabolic disorders of neurotransmitter cytokines. This article reviews the epidemiological characteristics, diagnostic criteria, pathophysiological mechanism and treatment strategies of PD comorbid depression and anxiety, in order to improve the NMS clinical management and quality of life of PD patients.
